Endocrine Abstracts

Introduction: The COVID-19 pandemic accelerated the execution of the 2019 NHS Long Term Plan with rapid introduction and widescale uptake of virtual consulting. While these are associated with lower Was Not Brought (WNB) rates, we observed that patients in our Paediatric and Adolescent Gynaecology (PAG) clinics were frequently absent, with parents (usually mothers) attending alone, unlike Face-To-Face (F2F) consultations, where the patients are always present....

Castrate Resistant Prostate Cancer (CRPC) is the inevitable outcome of hormone treatment for advanced disease. Although no longer dependent on high levels of androgens, the androgen receptor (AR) remains active and there is evidence that other nuclear receptors (NRs) can drive CRPC progression and/or therapy resistance. NRs share a repertoire of essential coregulators: proteins possessing the ability to aid or repress NR action and have been proposed as a potential mechanism f...

Introduction: Cinacalcet is an allosteric modulator of the calcium sensing receptor which lowers parathyroid hormone (PTH) secretion. However, it is expensive and there is limited evidence of benefit in reducing complications of primary hyperparathyroidism (PHPT). In 2019 the National Institute for Health and Care Excellence (NICE) guidelines suggested that cinacalcet could be considered in individuals with PHPT if surgery has been unsuccessful or is unsuitable and if adjCa<su...

Background: Neuroendocrine tumours (NETs) are a heterogenous group of slow growing tumours with an increasing incidence. Disease-related diarrhoea, surgery and medical treatment can lead to malabsorption, resulting in vitamin deficiencies.Objective: To establish the prevalence of vitamin deficiencies in patients with NETs.Method: Retrospective review of NET patients seen since 2014 in South Wales across 6 health boards. Deficiencie...

Introduction: ABCC8 gene mutations cause transient and permanent forms of neonatal diabetes with variable modes of inheritance. Almost all patients present with diabetes under 6 months old with rare cases upto 12 months. We report 2 siblings with diabetes and identical homozygous mutations of the ABCC8 gene, one of whom presented classically under 6 months old and the other unusually at 3 years of age.Cases: The index case, a British Pakistani f...

Case history: A 54-year-old lady was diagnosed with primary hypoparathyroidism in 2006, after being referred by her Rheumatologist as her father and brother had familial hypoparathyroidism and sensorineural deafness. She was followed up in endocrine clinic for management of primary hypoparathyroidism. Her hypocalcaemia is well managed with calcium supplementation, with no specific symptoms of hypocalcaemia. She has recurrent urinary tract infections with known borderline chro...

Background: Treatment of primary hyperparathyroidism (PHPT) and secondary hyperparathyroidism due to idiopathic hypercalciuria (SHPT-IH) is markedly different. Nevertheless, differentiating one from another remains a challenge and robust diagnostic tools are lacking. The thiazide challenge test (TCT) has been proposed as a means to aid clinicians in their decision making. However, evidence supporting its use is scarce.Materials and Methods: We performed ...

Case history: A 40-year-old, primaparous woman was referred at 24 weeks’ gestation to Obstetric Medicine for review of abnormal thyroid function tests (TFTs).Investigations: One year prior to pregnancy, TFTs included a thyroid stimulating hormone (TSH) level of 0.95 mU/l (local non-pregnant reference range 0.3–4.2 mU/l) and a free thyroxine level (fT4) of 7.3 mU/l (local non-pregnant reference range 9.0–23.0 mU/l). At 18 weeks’ gestat...

Czech Republic background: NordiNet® IOS (NCT00960128), a non-interventional study (2006–2016), assessed the effectiveness and safety of real-life treatment with Norditropin. From 23 countries, 2,321 adults with GHD were included; 971, GH-naïve at baseline, were included in the effectiveness analysis set (EAS). Baseline characteristics in the six largest contributing countries were evaluated.Methods: Patient information was ente...

Objective: Acromegaly is often accompanied by abnormalities in glucose and lipid metabolism, which tend to ameliorate upon treatment. However, few studies have investigated whether glucose homeostasis and lipid profiles are differently affected by different treatment regimens. This study aimed to compare glucose homeostasis and lipid profiles in patients with acromegaly who are well-controlled after surgery or under stable treatment with long-acting somatostatin analogs (SSA) ...